Registration Dossier
Registration Dossier
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EC number: 237-857-7 | CAS number: 14024-56-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Bis(pentane-2,4-dionato-O,O')magnesium
- EC Number:
- 237-857-7
- EC Name:
- Bis(pentane-2,4-dionato-O,O')magnesium
- Cas Number:
- 14024-56-7
- Molecular formula:
- C10H14MgO4
- IUPAC Name:
- magnesium;4-oxopent-2-en-2-olate
- Test material form:
- solid: particulate/powder
Constituent 1
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Cell source:
- foreskin from multiple donors
- Vehicle:
- unchanged (no vehicle)
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- The test item, Magnesium Acetylacetonate/N56, was a white powder. A nominal weight of 25 mg of the test item was applied to the tissue, previously wetted with 25 μL water (and spread over the surface of the tissue if required). A 25 mg application spoon (sharp spoon, NaCl weight 25 ~ 1 mg) was used to dispense the test item. A levelled spoonful of test item was weighed prior to the test to confirm the weight of the volume used.
The controls were in liquid form. A volume of 50 μL was dispensed over each tissue using a suitable pipette. - Duration of treatment / exposure:
- Duplicate tissues were dosed for three minutes and duplicate tissues dosed for one hour with test item, negative control or positive control.
- Number of replicates:
- 2 with 3 minutes contact
2 with 1 hour contact
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 1 (3 minutes contact)
- Value:
- ca. 105.1
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 2 (1 hour contact)
- Value:
- ca. 106.4
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The skin corrosion study was performed according to the OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method).
The test item was considered as non corrosive to the skin.
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