Methyl-tris acetonoximo-silane

Endpoint summary

Description of key information

No suitable data are available to assess the skin and eye irritation potential of the target substance Methyl-tris acetonoximo-silane. Thus, available data from WASOX-MMAC2 and EAC3 (source substances) were used in a read-across approach.

The source substance WASOX-MMAC2 was tested negative in an in vivo skin irritation study conducted according to OECD 404. The source substance EAC3 was tested negative in an in vivo eye irritation study conducted according to OECD 405. Based on the available data, the target substance can be considered as non-irritant to the skin and eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation: in vivo

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

The source compound WASOX-MMAC2 (A mixture of: propan-2-one-O,O'-(methoxymethylsilandiyl)dioxime; propan-2-one-O-(dimethoxymethylsilyl)oxime; propan-2-one-O,O',O''-(methylsilantriyl)trioxime; EC No. 460-110-3) is considered a suitable read across partner for the target substance MAC (CAS 2594-75-4). This read-across is based on the hypothesis that source and target substances have similar toxicological properties because:

- structural similarity of the target and the source substances (the presence or absence of additional functional groups or substituents that could influence the behaviour of a chemical),

- similarity in physico-chemical profile of the source and target substances (rapid decomposition in water under cleavage of the same substance (acetone oxime)).

Both substances are similar in terms of the substitution pattern at the silicon atom (i.e. acetoneoximo and methyl group(s)). Both substances exhibit consequently similar physico-chemical properties (rapid decomposition in water, decomposition upon heating to determine boiling point).

Reason / purpose for cross-reference:

read-across source

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritation parameter:

erythema score

Basis:

animal #3

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritation parameter:

edema score

Basis:

animal #1

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritation parameter:

edema score

Basis:

animal #2

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritation parameter:

edema score

Basis:

animal #3

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

All areas to be treated with the test substance and all contral areas were normal before the application and at each observation time. Moreover, no symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred.

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the results from a primary dermal irritation study conducted according to OECD guideline 404, the test item WASOX-MMAC2 can be considered as non-irritant to the skin.

Executive summary:

In a primary dermal irritation study conducted according to OECD guideline 404, 0.5 mL of the test item was applied to three New Zealand White rabbits for 4 hours under semi-occlusive conditions to a body surface area of 2.5 cm². Skin reactions were scored approximately 1, 24, 48 and 72 hours after patch removal. The test item did not cause any skin effects and is considered under the conditions of this study as nontoxic.

This information is used in a read-across approach in the assessment of the target substance.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vivo

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

The source compound EAC3 (2-propanone, 2,2’,2”-[O,O’,O”-(ethylsilylidyne)trioxime], EC No. 611-631-1) is considered a suitable read across partner for the target substance MAC (CAS 2594-75-4). This read-across is based on the hypothesis that source and target substances have similar toxicological properties because:

- structural similarity of the target and the source substances (the presence or absence of additional functional groups or substituents that could influence the behaviour of a chemical),

- similarity in physico-chemical profile of the source and target substances (rapid decomposition in water under cleavage of the same substance (acetone oxime)).

Both substances are similar in terms of the substitution pattern at the silicon atom (i.e. acetoneoximo and methyl group(s)). Both substances exhibit consequently similar physico-chemical properties (rapid decomposition in water, decomposition upon heating to determine boiling point).

Reason / purpose for cross-reference:

read-across source

Irritation parameter:

iris score

Basis:

mean

Remarks:

of three animals

Time point:

24/48/72 h

Score:

0

Max. score:

2

Remarks on result:

no indication of irritation

Irritation parameter:

chemosis score

Basis:

mean

Remarks:

of three animals

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritation parameter:

cornea opacity score

Basis:

mean

Remarks:

of three animals

Time point:

24/48/72 h

Score:

0

Max. score:

4

Remarks on result:

no indication of irritation

Irritation parameter:

conjunctivae score

Basis:

mean

Remarks:

of three animals

Time point:

24/48/72 h

Score:

0.33

Max. score:

3

Reversibility:

fully reversible within: 48 h

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

The eyes were examined 1, 24, 48 and 72 hours after the application.
One hour after the application: Conjunctival redness (score 1 or 2), conjunctival chemosis (score 1 or 2) and conjunctival discharge (score 2 or 3) were found in all animals.
24 hours after the application: Conjunctival redness (score 1) was found in all animals. In addition, conjunctival discharge (score 1) was noted in one animal.
48 and 72 hours after the application: No signs of eye irritation or other clinical signs were noted.
As all signs of eye irritation had fully reversed, the study was terminated after a period of 72 hours observation

Interpretation of results:

GHS criteria not met

Conclusions:

In an acute eye irritation/corrosion study conducted according to OECD 405, the test item is considered to be non-irritant.

Executive summary:

In a primary eye irritation study (OECD 405), 0.1 mL of the test item was instilled into the conjunctival sac of one eye of each of three male New Zealand White rabbits. The untreated eye served as control. Control and treated animals were observed at 1, 24, 48 and 72 hours after application. Irritation was scored by the method of Draize. Only very mild conjunctival reactions were noted, which were fully reversible within 48 hours. Based on the results, the test item can be considered as not irritating.

This information is used in a read-across approach in the assessment of the target substance.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

No suitable data are available to assess the skin and eye irritation potential of the target substance Methyl-tris acetonoximo-silane. Thus, available data from WASOX-MMAC2 and EAC3 (source substances) were used in a read-across approach.

The source substance WASOX-MMAC2 was tested negative in an in vivo skin irritation study conducted according to OECD 404. The source substance EAC3 was tested negative in an in vivo eye irritation study conducted according to OECD 405. Based on the available data, the target substance can be considered as non-irritant to the skin and eye.

Justification for classification or non-classification

Based on these results, the target substance Methyl-tris acetonoximo-silane does not warrant classification for skin and eye irritation in accordance to CLP regulation (EC) No 1272/2008.