Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-774-4 | CAS number: 5977-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 November 2017 - 17 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 25°C
- Details on study design: HPLC method:
- HPLC System: Agilent 1260 HPLC system
Column: EC 150/4.6 Nucleodur 100-5 CN-RP 150 x 4.6 mm; 5 1-1m
The analysis was performed on an analytical column packed with a commercially available cyanopropyl solid
phase containing lipophilic and polar moieties. A moderately polar stationary phase based on a silica matrix
was used (EC 150/4.6 Nucleodur 100-5 CN-RP 150 x 4.6 mm; 5 !Jm).
A of 55 % methanol I 45 % ultra-pure grade water was used as mobile phase and the column temperature
was 25°C ± 1 °C. - Analytical monitoring:
- no
- Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- ca. 1.32 dimensionless
- Temp.:
- 25 °C
- Matrix:
- Silica matric (HPLC)
- Remarks on result:
- other: HPLC method
- Remarks:
- pH value not measured
- Details on results (HPLC method):
- The log Koc values were below the lowest used reference standard (log Koc of the lowest reference
standard phenol is 1.32). Therefore the repeatability could not be determined. - Validity criteria fulfilled:
- yes
- Conclusions:
- The log Koc values were below the lowest used reference standard (log Koc of the lowest reference standard phenol is 1.32).
Therefore, the log Koc is < 1.32. - Executive summary:
The aim of this study was the determination of the adsorption coefficient of Acetoacetamide on soil and on sewage sludge (Koc) by high performance liquid chromatography (HPLC) method according to EC method
C.19 (440/2008) and OECD guideline 121.
The analysis was performed on an analytical column packed with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties. A moderately polar stationary phase based on a silica matrix
was used. A of 55 % methanol / 45 % ultra-pure grade water was used as mobile phase and the column temperature was 25°C ± 1 °C.
The log Koc values were below the lowest used reference standard (log Koc of the lowest reference standard phenol is 1.32).
Therefore, the log Koc is < 1.32.
Reference
Description of key information
The log Koc values were below the lowest used reference standard (log Koc of the lowest reference standard phenol is 1.32).
Therefore, the log Koc is < 1.32.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.