Registration Dossier
Registration Dossier
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EC number: 248-383-5 | CAS number: 27277-00-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Jun 2016 to 24 Aug 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 1995
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Qualifier:
- according to guideline
- Guideline:
- other: Council Regulation (EC) No 440/2008, Official Journal of the European Union, L 142
- Version / remarks:
- 31 May 2008
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 5.7 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 7.1
- Water solubility:
- 5 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 5.1
- Water solubility:
- 5.1 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 7
- Water solubility:
- 5.2 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 9.1
- Conclusions:
- The water solubility of the test item was determined to be 5.7 g/L in pure water. In buffered solutions at pH 5.1, 7.0 and 9.1, the water solubility ranged from 5.0 to 5.2 g/L
- Executive summary:
The solubility in water of the test item has been determined using the shake flask method in pure water and in aqueous buffer solutions at 20 °C to be:
- pure water pH 7.1 5.7: g/L
- buffered solution pH 5.1: 5.0 g/L
- buffered solution pH 7.0: 5.1 g/L
- buffered solution pH 9.1: 5.2 g/L
Reference
Description of key information
5.7 g/L at 20 °C, OECD 105, GLP, flask method, Halarnakar 2017
Key value for chemical safety assessment
- Water solubility:
- 5.7 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined to be 5.7 g/L in pure water. In buffered solutions at pH 5.1, 7.0 and 9.1, the water solubility ranged from 5.0 to 5.2 g/L
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