Registration Dossier
Registration Dossier
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EC number: 945-453-3 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The MCHAmix is acutely harmful to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 16.5 mg/L
Additional information
There are no experimental data on the acute toxicity of the reaction product of 2,4-Dinitrotoluene and 2.6-Dinitrotoluene and hydrogen, deaminated (MCHAmix, EC 943-517-5) to aquatic invertebrates. Therefore, a read-across approach was applied to 2-Methylcyclohexylamine (CAS 7003-32-9), which is one of the representative constituents of MCHAmix (EC 943 -517 -5), and to 2,6-dimethylcyclohexylamine (CAS 6850-63-1) which is a structurally similar substance.
Both available studies were performed according to OECD 202 using Daphnia magna as test species. Test solutions were not pH-adjusted; however, some of the test solutions in the study on 2 -methylcyclohexylamine (CAS 7003 -32 -9) were performed in parallel with pH-adjustment in order to investigate pH-effects of the test substance on the immobilisation.
The source chemical 2-Methylcyclohexylamine (CAS 7003-32-9) has a 48-h EC50 value was 16.5 mg/L (analytically verified, not pH-adjusted). Testing of pH-adjusted test concentrations at (25 to 100 mg/L) showed significantly lower inhibiting effects on mobility at 50 and 100 mg/L (48-h, BASF AG, 1987, rep. no.: 1/1130/2/87).
Based on the available experimental data, the source substance 2,6-dimethylcyclohexylamine (CAS 6850-63-1) has a 48-h EC50 value of 36.29 mg/L (nominal, BASF AG, 1987, rep. no.: 1/0306/2/87-0306). The results are based on nominal test concentrations in not pH-adjusted solutions.
As CAS 7003 -32 -9 had a higher effect on the immobilization, this study was selected as key study.
The target substance MCHAmix is considered to be acutely harmful to aquatic invertebrates.
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