Registration Dossier
Registration Dossier
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EC number: 226-901-0 | CAS number: 5538-94-3
Endpoint summary
Administrative data
Description of key information
In accordance with Annex IX of the REACH Regulation (EC) No. 1907/2006 toxicity studies in fish, aquatic invertebrates and algae have been conducted for the target substance, dioctyldimethyl ammonium chloride (C8DAQ). Studies for the read-across substances, didecyldimethyl ammonium chloride (DDAC) and DDACarbonate are also included in the dossier.
A reliable acute toxicity study with freshwater fish, Oncorhynchus mykiss for the test substance, C8DAQ is available, with a 96-hour LC50 (mortality) of 0.35 mg /L. This value will be taken as the short-term toxicity in fish endpoint for C8DAQ.
A reliable early life stage toxicity with freshwater fish Fathead minnow (Pimephales promelas) using the read-across substance N,N-Didecyl-N,N-dimethylammonium carbonate (DDACarbonate), provided a NOEC based on the most sensitive endpoint, growth, of 0.018 mg/L (18 µg/L).
A reliable acute toxicity study with the aquatic invertebrate Daphnia magna, and using the test substance C8DAQ is available with a 48-hour LC50 of 0.10 mg/L. This value will be taken as the short-term toxicity in aquatic invertebrates endpoint for C8DAQ.
A reliable long term toxicity study on the aquatic invertebrate, Daphnia magna, using the read across substance, N,N-Didecyl-N,N-dimethylammonium carbonate (DDACarbonate). The NOEC based on the most sensitive endpoint, growth, over a 21-day period, was determined at 27 µg AI/L and the LOEC 46 µg AI/L.
A reliable toxicity study with the freshwater alga Pseudokirchneriella subcapitata and using the test substance, C8DAQ is available, with a 72-hour ErC50 (growth rate inhibition) of 0.122 mg/L. The NOEC (growth rate inhibition) was determined to be 0.010 mg/L. This value will be taken as the toxicity in aquatic algae endpoint for C8DAQ.
A reliable toxicity study with microorganisms for the read-across substance DDAC is available, with a 3-hour EC50 of 11 mg /L. This value will be taken as the toxicity to microorganisms endpoint for C8DAQ.
A reliable toxicity study with the freshwater plant, Lemna gibba, using the read across substance N,N-Didecyl-N,N-dimethylammonium carbonate (DDACarbonate) is available, with a 7-day EC50's of 0.057 mg A.I /L and a NOAEC of 0.01234 µg A.I /L (based on frond growth). These are based on an average of the day 0 and day 7 exposure concentrations due to a large drop in concentration over the duration of the study.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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