Registration Dossier
Registration Dossier
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EC number: 310-288-2 | CAS number: 161907-78-4 A complex mixture of oxygenated hydrocarbons produced by the distillation of residues from the manufacture of ethylene glycol monoethyl ether. It consists predominantly of a mixture of di-, tri-, tetra- and pentaethylene glycol monoethyl ethers having carbon numbers predominantly in the range C6 to C12 and boiling in the range of approximately 200°C to 300°C (392°F to 572°F).
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
TEGME (measured) :-1.12
TEGBE (measured): 0.56
TEGEE (calculated): -0.96
TetraEGEE (calculated): -1.24
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.7
- at the temperature of:
- 20 °C
Additional information
There is no measured value available for the partition co-efficient of this substance. There is however measured data for two similar triethylene glycol ethers that can be used as read across substances and to justify the validity of a QSAR used to predict the value for the main components of this UVCB substance. 2-(2-(2 -methoxyyethoxy)ethoxy)ethanol (TEGME) has a measured value of -1.12 for log kow whereas 2-(2-(2 -butoxyyethoxy)ethoxy)ethanol has a value of 0.51. The value for 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol (TetraEGEE) will fall between these two values. The predicted values for the logkow using the Epiwin QSAR are shown below:
| Substance | Measured logKow | QSAR value |
| TEGME | -1.12 | -1.46 |
| TEGEE | -1.24 | |
| TEGBE | 0.51 | 0.02 |
The QSAR seems to underpredict by a value of about 0.35 to 0.45. The QSAR predicted values for the logKow of the two major components of this UVCB substance are -0.96 and -1.24 respectively. Assuming therefore a logKow somewhere midway and then correcting for the offset between the measured and predicted values for the substances where both values are available, would lead to an estimate for the logKow of ~-0.7. This value is taken forward as the key parameter for this end point. A justification for read across/interpolation is attached to chapter 13 of the lead registrant's dossier.
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