2-chloro-2-methylpropane

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2017-08-25 to 2017-11-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

51 °C

Atm. press.:

1 013.25 hPa

Decomposition:

no

Individual results (DSC measurement)

Two DSC measurements in open glass crucibles showed an exothermal effect in the temperature range of 20 - 90 °C. No further exothermic or endothermic effects were observed up to the final temperature (200 °C). The mass loss after the DSC measurements amounted to 100 %.

The results of the DSC measurements are summarized in table 1.

Table 1: Boiling point (DSC measurement)

Ident No.	Test item (mg)	Starting temperature (°C)	Final test temperature (°C)	Temperature range (endo- thermal) (°C)	Crucible	Observations after the measurement
36546	16.78	0	200	25 - 90	open glass	mass loss: 100%
36549	15.29	5	200	20 - 90	open glass	mass loss: 100%

According to DSC measurements the test item had a boiling range of 20 - 90 °C. In both DSC measurements an ambiguous onset of the endothermal effect was observed. Possibly the DSC measurements were influenced by the vapour pressure of the test item (see also mass loss during the open glass measurement with the final temperature of 10 °C for the melting point. Due to the ambiguous onset of the endothermal effect the data of the determination of the vapour pressure was used for the evaluation of the boiling point/range of the test item.

Calculation of boiling point via Antoine parameters

With the dynamic method the vapour pressure was measured in the temperature range of 10 °C to 47 °C. Using the Antoine constants A, B and C and the pressure of 1013.25 hPa the boiling temperature is calculated to be 50.9 °C (see below table 2).

Table 2: Antoine parameters and extrapolated vapour pressures

log (p/hPa) = A + B/(C+T[°C])	p (hPa)	T (°C)
A = 5.346	1013.25	51.0
B =-411.1
C = 124.7

The test item had a mean boiling point at atmospheric pressure (1013.25 hPa) of 51.0 °C.

Conclusions:

The boiling point of the test item was determined to be 51.0 °C at 1013.25 hPa.

Executive summary:

A study was performed according to OECD TG 103 and Commission Regulation (EC) No. 440/2008 method A.2. in order to determine the boiling point of the test item by using differential scanning calorimetry method (DSC). Two DSC measurements were performed in open crucibles. An endothermal effect was observed in the temperature range of approximately 20 to 90 °C. The mass loss after the DSC measurements was 100 %. Due to the ambiguous onset of the endothermic effect it was assumed that the vapour pressure of the test item influenced the measurements. Hence the determination of the vapour pressure was used for evaluation of the boiling point. Using the Antoine constants A, B and C and the pressure of 1013.25 hPa the boiling temperature of the test item was determined to be 51.0 °C.

Description of key information

The boiling point of the test item was determined to be 51.0 °C at 1013.25 hPa.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

51 °C

Additional information

A study was performed according to OECD TG 103 and Commission Regulation (EC) No. 440/2008 method A.2. in order to determine the boiling point of the test item by using differential scanning calorimetry method (DSC). Two DSC measurements were performed in open crucibles. An endothermal effect was observed in the temperature range of approximately 20 to 90 °C. The mass loss after the DSC measurements was 100 %. Due to the ambiguous onset of the endothermic effect it was assumed that the vapour pressure of the test item influenced the measurements. Hence the determination of the vapour pressure was used for evaluation of the boiling point. Using the Antoine constants A, B and C and the pressure of 1013.25 hPa the boiling temperature of the test item was determined to be 51.0 °C (reference 4.3-1).