Chlorimuron ethyl

Toxicity to birds

Administrative data

Endpoint:

long-term toxicity to birds: reproduction test

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Quail were exposed to the appropriate dietary concentrations for five days, and then maintained on basal (toxicant-free) diet for an additional three-day observation period. The control birds received the basal diet with 2% w/w corn oil for the five day exposure period, and basal diet only for the three day observation period.

Symptoms of toxicity and mortality were recorded daily throughout the study. Body weights were recorded by pen at initiation of the study, on Day 5, and at the termination of the study on Day 8. Feed consumption was recorded by pen during the five-day exposure period and during the three-day observation period. Feed consumption was measured accurately, but is presented as an estimate due to the unavoidable wastage by the birds.

GLP compliance:

no

Test material

Test material information

1

Reference substance name:

ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate

EC Number:

618-690-2

Cas Number:

90982-32-4

Molecular formula:

C15H15ClN4O6S

IUPAC Name:

ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate

Test material form:

solid: particulate/powder

Details on test material:

Purity: 96%

Dose method:

feed

Analytical monitoring:

no

Vehicle:

no

Test organisms

Test organisms (species):

Colinus virginianus

Study design

Total exposure duration (if not single dose):

8 d

Post exposure observation period:

3 d

No. of animals per sex per dose and/or stage:

10

Control animals:

yes, plain diet

Nominal and measured doses / concentrations:

562, 1000, 1780, 3160, and 5620 ppm

Examinations

Reference substance (positive control):

yes

Remarks:

Dieldrin

Results and discussion

Effect levels

Duration (if not single dose):

8 d

Dose descriptor:

LC50

Effect level:

> 5 620 other: ppm

Conc. / dose based on:

test mat.

Basis for effect:

mortality

Mortality and sub-lethal effects:

There was no mortality in any of the control or test birds

Results with reference substance (positive control):

The most recent positive control with dieldrin, run on January 13, 1983, yielded an LC50 value of 30 ppm, with confidence limits of 25 ppm to 36 ppm. This falls within two standard deviations of the historical positive control values from studies run since July 12, 1977 of 38 ppm ± 5 ppm (SD).

Any other information on results incl. tables

Body weight and estimated feed consumption of bobwhite quail exposed to DPX-F6025 for five days

 

Concentration of DPX-F6025	Average body weight on day 0	Average body weight on day 5	Average body weight on day 8	Feed consumption (F.C.) Days 0-5	Feed consumption (F.C.) Days 6-8	F.C./bird/day (Days 0-5)	F.C./bird/day (Days 6-8)
0	27 g	39 g	47 g	425 g	308 g	9	10
0	27 g	40 g	48 g	552 g	303 g	11	10
0	30 g	43 g	52 g	521 g	306 g	10	10
0	30 g	45 g	52 g	454 g	326 g	9	11
0	27 g	40 g	48 g	472 g	280 g	9	9
562 ppm	29 g	44 g	53 g	379 g	249 g	8	8
1000 ppm	30 g	46 g	55 g	414 g	254 g	8	8
1780 ppm	30 g	44 g	53 g	413 g	292 g	8	10
3160 ppm	32 g	46 g	55 g	469 g	274 g	9	9
5620 ppm	31 g	46 g	56 g	447 g	313 g	9	10

 

Applicant's summary and conclusion

Validity criteria fulfilled:

no

Conclusions:

The test substance did not cause overt symptoms of toxicity or behavioral abnormalities at any concentration level tested. There were no mortalities at any concentration level tested. There appeared to be a slight reduction in feed consumption at the 562 ppm through 1780 ppm concentration levels for the first five days of the study and a slight reduction in feed consumption at 562 ppm and 1000 ppm concentration levels for the final three days of the study. There was no effect on body weight gain at any concentration level.

Executive summary:

Quail were exposed to the appropriate dietary concentrations for five days, and then maintained on basal (toxicant-free) diet for an additional three-day observation period. The control birds received the basal diet with 2% w/w corn oil for the five day exposure period, and basal diet only for the three day observation period.

The test substance did not cause overt symptoms of toxicity or behavioral abnormalities at any concentration level tested. There were no mortalities at any concentration level tested. There appeared to be a slight reduction in feed consumption at the 562 ppm through 1780 ppm concentration levels for the first five days of the study and a slightreduction in feed consumption at 562 ppm and 1000 ppm concentration levels for the final three days of the study. There was no effect on body weight gain at any concentration level.