Registration Dossier
Registration Dossier
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EC number: 216-036-7 | CAS number: 1478-61-1
Endpoint summary
Administrative data
Description of key information
With an experimental log Kow value at 2.79 (Bär, 2017), the substance is not expected to bioaccumulate in aquatic organisms and does not meet the bioaccumulative (B) or very bioaccumulative (vB) screening criterion (log Kow < 4.5). This is confirmed with experimental fish BCF values between 5.2 and 9.8 L/kg (Shi et al., 2016), well below the cut-off values of 2000 L/kg. In addition, at the end of a 24 h depuration phase, 80 % of whole fish BPAFconcentrations had dissipated demonstrating that the substance was rapidly eliminated from the fish. The results conclude that the registered substance, BPAF, is not considered bioaccumulative in aquatic organisms.
Equivalent to log Kow for bioaccumulation in aquatic organisms, log Koa (octanol-air partition coefficient) has been recognised as a parameter indicating that bioaccumulation can occur in air-breathing (terrestrial) organisms. Available information on log Koa and log Kow as provided in the Integrated Testing Strategy for B-assessment of the ECHA Guidance Chapter R.11 (June 2017) may indicate if the substance is potentially bioaccumulative in air-breathing organisms (log Kow > 2 AND log Koa > 5). Based on the log Kow at 2.79 and an estimated Henry's Law Constant of 4.2E-06 Pa.m³/mol at 12°C (calculated with the vapour pressure value: 5E-06 Pa at 20°C; water solubility value: 222.4 mg/L at 20°C; and molecular weight of the substance: 336.229 g/mol), the registered substance has an estimated log Koa at 11.54, indicating potential to bioaccumulate in air-breathing organisms. However, the toxicokinetics (TK) of BPAF studied by Li et al., (2013, seen in IUCLID Section 7) showed that it was “eliminated completely at 48 hrs” following oral dosing in rats, and was metabolized quickly. Recent toxicokinetics studies in rats and mice (Waidyanatha et al, 2019, NTP) found plasma elimination half-lives of less than 4.22 h in rats and mice and extensive conjugation leading to low bioavailability. These data indicate that the registered substance is not likely to bioaccumulate in mammals.
Additional information
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