Registration Dossier
Registration Dossier
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EC number: 434-280-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Skin irritation: Irritant
Eye irritation: Irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Dermal irritation:
(Superficial) grey- yellowish discolouration of the skin (sign of necrosis), reduced flexibility and fissuring of the skin was noted among the animals between 24 hours and 7 days after exposure. Scaliness and bald skin were noted in all animals after 14 days. No skin abnormalities were noted in the animals after 21 days.
Corrosion
There was no evidence of a corrosive effect on the skin.
Eye irritation
Instillation of 0 .1 ml of the test substance into one eye of each of three rabbits resulted in effects on the cornea, iris and conjunctivae.
Corneal injury was seen as opacity (maximum grade 1 ) and epithelial damage (maximum 25 or 50 % of the corneal area). The corneal injury had resolved within 72 hours in two animals and within 7 days in the other animal.
lridial irritation (grade 1 ) was observed which had resolved within 24 or 72 hours or within 7 days.
Irritation of the conjunctivae was seen as redness, chemosis and discharge, which had completely resolved within 1 4 days in all animals.
Corrosion
There was no evidence of ocular corrosion.
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