N-(2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

Density

Administrative data

Endpoint:

bulk density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental Starting Date: 11 October 2012. Experimental Completion Date: 25 January 2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

air comparison pycnometer (for solids)

Test material

Test material information

Constituent 1

Reference substance name:

N4-Benzoylcytosine

EC Number:

628-907-2

Cas Number:

26661-13-2

Molecular formula:

C11H9N3O2

IUPAC Name:

N4-Benzoylcytosine

Specific details on test material used for the study:

Identification: N-Benzoyl Cytosine
Description: Off white powder
Batch: NBC-5-11001
Purity: ≥ 95.0%
Expiry / Retest Date: Not supplied
Storage Conditions: Room temperature in the dark over silica gel

Results and discussion

Density

Key result

Type:

bulk density

Density:

1 480 kg/m³

Temp.:

21.2 °C

Any other information on results incl. tables

The pressure readings and the calculated volume for the reference and sample cells are shown in the following table:

Determination	P1	P2	P3	P4	Reference Cell Volume (cm3)	Sample Cell Volume (cm3)
1	17.215	6.516	17.178	8.512	90.659	148.858
2	17.207	6.516	17.357	8.602	90.793	148.967
3	17.053	6.461	17.167	8.51	90.916	149.046

The pressure readings, calculated volumes and density values obtained for the test item are shown in the following table:

Determination	Test	P1	P2	Volume (cm3)	Density (kg/m3)	Mean Density (kg/m3)
1	A	17.406	6.823	8.136	1460	1470
	B	17.171	6.728	8.036	1470
	C	17.214	6.742	7.938	1490
2	A	17.189	6.79	9.911	1480	1480
	B	17.187	6.767	9.157	*1600
	C	17.153	6.776	9.919	1480

Temperature: 21.2 ± 0.5 ºC

Mean density: 1480 kg/m3

*The density value for Determination 2 Test B was considered to be out-of-agreement with the other five results, and was therefore not used in the subsequent calculations.

Applicant's summary and conclusion

Conclusions:

The density of the test item has been determined to be 1480 kg/m3 at 21.2 ± 0.5 °C.

Executive summary:

1480 kg/m³ at 21.2 ± 0.5 °C, using a gas comparison pycnometer, designed to be compatible with Method A3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.