Registration Dossier
Registration Dossier
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EC number: 268-582-0 | CAS number: 68130-25-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- other justification
- Justification for data waiving:
- the study need not be conducted because (i) inhalation of the substance is likely and (ii) skin contact in production and/or use is not likely and (iii) the physicochemical and toxicological properties suggest no potential for a significant rate of absorption
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
Dermal toxicity is unlikely to result in a more severe classification than the corresponding oral hazard, therefore we can read across from the acute oral GHS classification and use the same classification for acute dermal toxicity.
Currently we can confirm that
• Acute oral toxicity is not classified.
• The 14 day repeat oral dose study shows no systemic effects.
• 28 day repeat dose NOAEL 1000mg/kg/day.
• High molecular weight confirms low permeability through the skin (greater than 500 MW)
• Partition coefficient value (Log Pow >6.5) also indicates low permeability through the skin
Based on the information listed above we can confirm dermal toxicity is unlikely and endpoint is considered as non hazardous.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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