Registration Dossier
Registration Dossier
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EC number: 927-186-4 | CAS number: -
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- BIBR 1048 Amidin TS RS1
- IUPAC Name:
- BIBR 1048 Amidin TS RS1
- Test material form:
- other: solid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Duration of test (contact time):
- 28 d
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (test mat. analysis)
- Value:
- ca. 18
- Sampling time:
- 10 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- ca. 38
- Sampling time:
- 28 d
Applicant's summary and conclusion
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The test item was tested using a concentration of 2.4 mg/L (corresponding to a theoretical oxygen consumption of 5.8 mg/L) in test medium
following OECD 301 D and EUGuideline C.4-E. Sodium benzoate was chosen as reference item. Effluent from asewage treating plant was used as
inoculum (cone. 0.5 mL effluent /L medium). The test was left running for 28 days.All validity criteria were met. Degradation of the reference item
was 78 % after five days. The Oruptake caused by nitrification was considered for the determination of the degradation.
The following data could be determined for the test item BIBR 1048 Amidin TS RS1:
10-day-window: day 4 - 14
degradation at the end of 10-day-window 18%
degradation at the end of the test 38 %
pass level: 60% at the end of 10-d-window
Therefore BIBR 1048 Amidin TS RS1 is not readily biodegradable following OECD 301 D/EU C.4-E.
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