Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-276-9 | CAS number: 114959-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-08-14 to 1991-08-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection 1990-05-14
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Benzoic acid, 2-hydroxy-, mono-C14-18-alkyl derivs., calcium salts (2:1)
- EC Number:
- 931-276-9
- Cas Number:
- 114959-46-5
- Molecular formula:
- See information in Section 1.2.
- IUPAC Name:
- Benzoic acid, 2-hydroxy-, mono-C14-18-alkyl derivs., calcium salts (2:1)
- Details on test material:
- - Name of test material (as cited in study report): [CAS Number 114959-46-5]
- Physical state: Clear brown viscous liquid
- Lot/batch No.: 191 (Stanlow); DSP4767/91
- Toxicology reference number: ST91/247
- Stability under test conditions: Stable for the duration of the study under the test conditions employed
- Storage condition of test material: In the dark at ambient temperature under nitrogen
- Date received: 08 August 1991
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK Ltd
- Age at study initiation: 8-9 weeks
- Weight at study initiation: 195-219 g (males); 137-155 g (females)
- Fasting period before study: Overnight
- Housing: Single sex groups of up to 5 rats to a cage during quarantine; Single sex groups of up to 3 rats to a cage for at least five days prior to dosing in cages with stainless steel wire-mesh walls floors and tops. Each cage measured 33 cm x 22 cm x 16 cm. Paper-lined trays for excreta were placed beneath each cage and changed three times weekly.
- Diet (e.g. ad libitum): Pelleted diet (LAD 1, Special Diets Services Ltd) ad libitum
- Water (e.g. ad libitum): Water from the public supply ad libitum
- Acclimation period: Minimum of four days quarantine in non-barried animal room with access restricted to essential personnel plus five days acclimation prior to dosing
ENVIRONMENTAL CONDITIONS
- Temperature: 19-23 degrees Centigrade with no excursions considered to have influenced the experimental outcome
- Humidity: 30-70 % with no excursions considered to have influenced the experimental outcome
- Photoperiod: 12 hour day and 12 hour night provided by automatically controlled fluorescent lighting
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Fasted animals were weighed and given a single dose of test material by gavage using a ball pointed cannula and syringe. The animals were permitted food ad libitum approximately 2.5 hours after dosing on Day 1.
- Doses:
- Single doseof 5000 mg/kg administered as a dose volume of 4.76 mL/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- Animals assigned to the study were identified by cage labels displaying the animal numbers, experiment number, sex and test material and by ear-notches denoting the animal number.
A detailed clinical examination was made seven times daily on the day of dosing (Day 1) and twice daily thereafter for the remainder of the 14 day observation period. The initial (Day 1), Day 8 and Day 15 bodyweights were recorded and changes in bodyweight calculated.
All animals were subject to necropsy. Animals were killed by an intraperitoneal injection of sodium pentobarbitone on Day 15. External surfaces and orifices were checked and the cranial, thoracic and abdominal cavities and viscera were examined. Any gross pathological changes were recorded. - Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died
- Clinical signs:
- other: All rats developed a hunched posture, diarrhoea and an unkempt appearance within 2.5 hours of dosing. Anogenital fur staining (yellow) also affected all rats by Day 2. Other clinical signs were limited to isolated cases of piloerection. Recovery, as judge
- Gross pathology:
- No macroscopic changes were apparent during necropsy of the rats on Day 15.
- Other findings:
- No data
Any other information on results incl. tables
Table 1 - Mortality following acute oral administration of test material to rats (attached)
Table 2 - Bodyweight and bodyweight change following acute oral administration of test material to rats (attached)
Table 3 - Clinical observations following acute oral administration of test material to rats (attached)
Table 4 - Necropsy findings in rats following a single dose of test material (attached)
Applicant's summary and conclusion
- Conclusions:
- The acute oral LD50 of the test material in fasted rats was greater than 5000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.