Tetrachloro-p-benzoquinone

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: All information on this study is derived from the review article BUA Report 85, as the complete study report is not at hand. The testing laboratory report no. is 002388

Data source

Reference

Reference Type:

review article or handbook

Title:

BUA Report 85, Ref. Hazleton 1990b

Author:

Beratergremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker (BUA)

Year:

1992

Bibliographic source:

Hirzel Verlag, Stuttgart

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

not specified

Remarks:

as only the respective review article is at hand

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tetrachloro-p-benzoquinone

EC Number:

204-274-4

EC Name:

Tetrachloro-p-benzoquinone

Cas Number:

118-75-2

Molecular formula:

C6Cl4O2

IUPAC Name:

2,3,5,6-tetrachloro-1,4-benzoquinone

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

other: 10% (w/v) gum arabicum dispersed in water

Details on dermal exposure:

The test material, was administered as a paste with 96.47% (w/v) chloranil in an aqeuous dispersion of 10% (w/v) gum arabicum. This paste was applied onto the shaved, intact skin of the back and hind part of the body.

Duration of exposure:

24 hours

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5 males + 5 females

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 95% CL could not be determined, as only one dose was tested.

Mortality:

no mortality

Clinical signs:

other: no intoxication symptomes, no skin lesions

Gross pathology:

no notable macroscopic findings

Any other information on results incl. tables

There were no premature deaths, signs of intoxication or skin lesions following 24 hours of semi-occlusive dermal exposure to the test substance at 2000 mg/kg bw. At the end of the 14-day observation period, toxicologically relevant macroscopic pathology findings were not evident.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

LD50: >2000 mg/kg bw

Executive summary:

2,3,5,6-tetrachloro-1,4-benzoquinone was tested for its acute dermal toxicity similar to OECD Guideline 402. Reliability grade 4 (reliability not assignable) was assigned to the study, as all information on this study was attained only from a review article.

 

Over a period of 24 hours, five male and five female Sprague-Dawley rats were exposed to the test substance at the limit dose of 2000 mg/kg bw by semi-occlusive administration onto shaved, intact skin on their back and hind part. A paste with 96.47% (w/v) of the test substance in an aqeuous dispersion of 10% (w/v) gum arabic was administered. Treatment was followed by a 14-day observation period. Mortality/survival, clinical signs, skin lesions and gross necropsy findings were recorded.

 

The test substance did not cause premature deaths, signs of intoxication or skin lesions. At necropsy toxicologically relevant macroscopic pathology findings were not evident.