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Diss Factsheets
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EC number: 946-061-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-02-23 to 1998-03-20
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- ((adopted 17-07-1992)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- (adopted 31-07-1992)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Remarks:
- TOC analysis
- Details on sampling:
- - Concentrations: 5, 10, 22, 50 mg/L
- Vehicle:
- no
- Details on test solutions:
- 24 h stirring
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zenbra fish
- Strain:Hamilton-Buchanan
- Source: own breed HMR Deutschland GmbH, Global Preclinical Development - Drug Safety
- Length at study initiation (length definition, mean, range and SD): 2.8 cm (2.6 - 3.0 cm / s = 0.13) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 21.1 - 21.8 °C
- pH:
- 7.1 - 8.2
- Dissolved oxygen:
- 5.9 - 9.8 mg/L
basin of 10 mg/L group was ventilated after 72 h
basin of 22 mg/L group was ventilated after 48 h - Nominal and measured concentrations:
- nominal: 0, 5, 10, 22, 50 mg/L
mean measured: 0, 2.36, 7.19, 21.75, 69.02 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: no data
- Aeration: yes (10 mg/L group was aerated starting at 72 h, 22 mg/L group was aerated starting at 48 h with a bubble frequence of 1-3 /s)
- No. of organisms per vessel: no data
- No. of vessels per concentration (replicates): no data
- No. of vessels per control (replicates): no data
TEST MEDIUM / WATER PARAMETERS
- no data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
mortality, abnormal behaviour atfer 24, 48, 72, 96 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2 - 2.27 - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 9.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% c.i. 5.5 - 14.3 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - at 5 mg/L no mortality or sublethal effects were noted, at 10, 22 and 50 mg/L mortality and sublethal effects were observed
- Mortality of control: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: - Reported statistics and error estimates:
- Probit analysis
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 96 LC50 of Polyoxyethylene(1 to 2.5) oleyl ether carboxylic acid was 9.1 mg/L (95% c.i. 5.5 - 14.3 mg/L) based on nominal concentrations.
- Executive summary:
In a 96-h acute toxicity study according to OECD Guideline 203 (1992) and EU method C.1 (1992), zebrafish (Danio rerio) were exposed to Polyoxyethylene(1 to 2.5) oleyl ether carboxylic acid at nominal concentrations of 0 (control), 0, 5, 10, 22, 50 mg/L under static conditions. Mean measured concentrations (TOC analysis) were 0, 2.36, 7.19, 21.75, 69.02 mg/L. Turbidity was observed in all test solutions, and measured concentrations differed 47.2 - 138% from nominal. Thus, effect concentrations are given as nominal.
The 96 LC50 of Polyoxyethylene(1 to 2.5) oleyl ether carboxylic acid was 9.1 mg/L (95% c.i. 5.5 - 14.3 mg/L) based on nominal concentrations.
At 5 mg/L no mortality or sublethal effects were noted, at 10, 22 and 50 mg/L mortality and sublethal effects were observed
This toxicity study is classified as acceptable and satisfies the guideline requirement for an acute toxicity study with zebrafish (Danio rerio).
Results Synopsis
Test Organism Size/Age: Danio rerio
Test Type: Static
96 h LC50: 9.1 mg/L (95% c.l. 5.5 - 14.3 mg/L), nominal
Endpoint(s) Effected: Mortality
Reference
Description of key information
96 LC50 = 9.1 mg/L (95% c.i. 5.5 - 14.3 mg/L), nominal (Danio rerio) (RL2, GLP; OECD TG 203/EU method C.1)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 9.1 mg/L
Additional information
In a 96-h acute toxicity study according to OECD Guideline 203 (1992) and EU method C.1 (1992), zebrafish (Danio rerio) were exposed to Polyoxyethylene(1 to 2.5) oleyl ether carboxylic acid at nominal concentrations of 0 (control), 5, 10, 22, 50 mg/L under static conditions. Mean measured concentrations (TOC analysis) were 0, 2.36, 7.19, 21.75, 69.02 mg/L. Turbidity was observed in all test solutions, and measured concentrations differed 47.2 - 138% from nominal. Thus, effect concentrations are given as nominal.
The 96 LC50 of Polyoxyethylene(1 to 2.5) oleyl ether carboxylic acid was 9.1 mg/L (95% c.i. 5.5 - 14.3 mg/L) based on nominal concentrations.
At 5 mg/L no mortality or sublethal effects were noted, at 10, 22 and 50 mg/L mortality and sublethal effects were observed
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