Registration Dossier
Registration Dossier
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EC number: 204-259-2 | CAS number: 118-55-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Conclusions:
- Ames test performed on salmonella typhimurium; strain TA100, 1535, TA1537, TA98 (performed (i) without metabolic activation; (ii) with rat, liver S9 and (iii) with hamster liver S9) are all negative.
Data on Ames test are inconclusive for the assessment of the germ cell mutagenicity of the substance.
Reference
Ames test performed on salmonella typhimurium; strain TA100, 1535, TA1537, TA98 (performed (i) without metabolic activation; (ii) with rat, liver S9 and (iii) with hamster liver S9) are all negative.
Additional information
Justification for classification or non-classification
Data on Ames test are inconclusive for the assessment of the germ cell mutagenicity of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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