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EC number: 232-263-4 | CAS number: 7803-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
There are no in vitro or in vivo data on the toxicokinetics of silane (CAS 7803-62-5; EC No. 232-263-4). The following summary has therefore been prepared based on validated predictions of the physicochemical properties of the substance. For the purposes of this summary only qualitative statements or predictions will be made.
Silane (SiH4) is an inorganic gas at standard temperature and pressure. It ignites spontaneously in air. Pure silane does not react with pure water, but in the presence of trace alkali, hydrolysis to silica (SiO2.nH2O) and hydrogen is rapid and complete. The relevant route of exposure to humans is inhalation of the gas.
Absorption
Oral
Significant oral exposure is not expected for this pyrophoric substance. Should it occur then gastrointestinal absorption of insoluble silica gel will be minimal (Carlisle, 1986).
Dermal
Significant dermal exposure is not expected for this pyrophoric substance. Should it occur then the parent substance is expected to react with moisture on the skin producing insoluble silicon dioxide which would not be absorbed.
Inhalation
Silane has a low molecular weight and reasonable water solubility and is therefore expected to penetrate the lower respiratory tract. The acute inhalation data available for silane indicate that it (or hydrolysis products) was absorbed as there were adverse effects on the kidneys in an acute study (Takebayashi, 1993).
Distribution
Since silica is insoluble, it would probably precipitate in the blood following hydrolysis of silane. Pathological examinations in one of the acute inhalation studies (Tabebayashi, 1993) revealed signs of silica precipitate reaching the kidneys, spleen, bone marrow and thymus (macrophage activity).
Metabolism
Pure silane does not react with pure water, but in the presence of trace alkali, hydrolysis to silica (SiO2.nH2O) and hydrogen is rapid and complete. Since the pH of the lung epithelium is neutral, hydrolysis would not be expected. In support of this is the finding that there were no silicosis-type effects in the lungs of animals used in the repeated dose toxicity study; however, the study might not have been of sufficient duration (four weeks) to show such effects. Blood has a pH of 7.35–7.45, so hydrolysis is possible once silane has been absorbed into the bloodstream.
Excretion
Some inhaled gas is likely to be exhaled before absorption can occur. Some hydrogen following hydrolysis, might also be excreted via exhaled air. Silica is excreted via the kidneys in urine.
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