Registration Dossier
Registration Dossier
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EC number: 254-296-3 | CAS number: 39108-47-9
Endpoint summary
Administrative data
Description of key information
Stability
Hydrolysis
According to literature data of Harris (1990), Kollig et al. (1993) and Boethling & Mackay (2000) hydrolysis of the substance is not expected.
Biodegradation
Biodegradation in water: screening tests
Based on data available for the close structural analogue 1-Ethyl-2-hydroxy-3-cyan-4-methylpyridon-6 (CAS 28141-13-1), the substance is qualified as not readily biodegradable.
Transport and distribution
Adsorption / desorption
Adsorption to solid soil phase is not expected. For the substance a log Koc value of 1 was calculated based on the MCI method.
Additional information
Biodegradation
Biodegaradation in water: screening tests
The biodegradation potential of the read-across substance 1-Ethyl-2-hydroxy-3-cyan-4-methylpyridon-6 (CAS 28141-13-1) in water was determined in a screening study according to OECD TG 301A (DOC Die Away Test) and in compliance with GLP criteria (BASF, 1999). In this study 90 mg/L test substance (equivalent to 20 mg/L DOC) was inoculated with non-adapted activated sludge from laboratory wastewater plants treating municipal sewage for 28 days under aerobic conditions. During the incubation period the degree of biodegradation is determined as removal of dissolved organic carbon (DOC). Based on DOC measurements it was determined that after the 28-day incubation period <10% of the substance was biodegraded. Based on these findings, ethylpyridon is assessed to be not readily biodegradable. Increased alkyl-chain length on cyclic substances is generally associated with decreased biodegradation potential of such a substance (OECD, 1993*). Therefore, it may be considered likely that the conclusion of non-ready biodegradation applies also to the target substance 1-butyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile.
* OECD (1993). Environment Monograph No. 68; Structure-Activity Relationships for Biodegradation. OECD/GD(93)126; Paris
Transport and distribution
Adsorption / desorption
A QSAR calculation with KOCWIN (v2.00) based on the MCI method was done and determined a log Koc of 1.0. The substance falls within the applicability domain of the (Q)SAR model. Hence, adsorption to solid soil phase is not expected.
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