Registration Dossier
Registration Dossier
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EC number: 236-244-1 | CAS number: 13254-34-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method in Federal Register 38(187)1500.41, S.27019,1973.
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP introduction
Test material
- Reference substance name:
- 2,6-dimethylheptan-2-ol
- EC Number:
- 236-244-1
- EC Name:
- 2,6-dimethylheptan-2-ol
- Cas Number:
- 13254-34-7
- Molecular formula:
- C9H20O
- IUPAC Name:
- 2,6-dimethylheptan-2-ol
- Reference substance name:
- Unknown impurities
- Molecular formula:
- not applicable
- IUPAC Name:
- Unknown impurities
- Test material form:
- liquid
Constituent 1
impurity 1
- Specific details on test material used for the study:
- Product: 2,6-Dimethylheptanol -2 (liquid)
Substance No.: 77/278
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
Results and discussion
In vivo
Results
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Primary irritation index: 20.5 / 4 = 5.13
Alterations were observed already after a short period of exposure. The irritations were reversible within 8 days after a short period of exposure, but not so after a 24-hour exposure. Based on the findings the substance must be considered to be strongly irritant (light redness and swelling. Flaking and overlapping redness were observed.)
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Based on the findings the substance must be considered to be moderately irritant.
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