Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-929-3 | CAS number: 76-05-1
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1997
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Reproductive and Developmental Toxicity of Degradation Products of Refrigerants in Experimental Animals
- Author:
- Ema M et al.
- Year:
- 2 010
- Bibliographic source:
- Reproductive toxicology 29, 1-6
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Female rats were exposed by oral route to trifluoroacetic acid during the gestation (from day 10 to day 20). On day 21, the delivery occured and then the pups were examined until day 49 postnatal (PND 49).
- GLP compliance:
- not specified
- Remarks:
- No information available.
- Limit test:
- no
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on mating procedure:
- not indicated
- Duration of treatment / exposure:
- 10 days: the test substance was administered from GD 10 to GD 20.
- Frequency of treatment:
- daily
- Duration of test:
- not indicated
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 75, 150 mg/kg bw/d
Basis:
nominal in water
- No. of animals per sex per dose:
- not indicated (around 40 pregnant females per dose and control)
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- > 150 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
Effect levels (fetuses)
- Basis for effect level:
- other: not specified
- Remarks on result:
- not determinable because of methodological limitations
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
