Registration Dossier
Registration Dossier
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EC number: 205-793-9 | CAS number: 151-56-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance and not a full compliance with guidelines because it only determines the diuretic activity.
Data source
Reference
- Reference Type:
- publication
- Title:
- THE EFFECT OF CERTAIN ETHYLENEIMINES ON RENAL FUNCTION
- Author:
- JACKSON J, JAMES RMV
- Year:
- 1 963
- Bibliographic source:
- Brit. J. Pharmacol. (1963), 21, 581-589.
Materials and methods
- Objective of study:
- other: diuretic propierties
- GLP compliance:
- no
Test material
- Reference substance name:
- Aziridine
- EC Number:
- 205-793-9
- EC Name:
- Aziridine
- Cas Number:
- 151-56-4
- Molecular formula:
- C2H5N
- IUPAC Name:
- aziridine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 260 to 320 g
- Housing: metabolism cages
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- One administration i.p.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.6, 1.2 and 2.5 mg/kg bw ethyleneimine
- No. of animals per sex per dose / concentration:
- groups of 5 animals
- Control animals:
- yes
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled (delete / add / specify): urine
- Time and frequency of sampling: continuosly, observation period until 5 days
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- An increase in the output of urine became apparent about 2 hr after administration of the drug, and the duration of the polyuria depended upon the dose of compound used.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
No more available data on the results.
Applicant's summary and conclusion
- Conclusions:
- Ethyleneimine causes a diuresis.
- Executive summary:
Certain simple derivatives of ethyleneimine cause an intense and prolonged diuresis in nonhydrated rats. Sodium, potassium and chloride excretion is unaffected by these compounds. Ethyleneimine also causes a diuresis in the rat, but the polyfunctional compound thiotepa is ineffective. The relationship between structure and activity of a number of compounds is discussed with particular reference to the possibility that the diuresis is due to the in vivo liberation of ethyleneimine.
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