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Diss Factsheets
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EC number: 269-246-6 | CAS number: 68201-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- May from 13th to 18th, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Internal method JIS - 0102, 1974
- GLP compliance:
- no
- Details on test organisms:
- TEST ORGANISM
- Common name: orange-red killifish.
- Order: cyprinodontiformes.
- Average weight: 0.27 g
- Average length: 3.1 cm
- Selection: fish passed mercuric-chloride inspection. - Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Test temperature:
- 25 ± 1 °C
- pH:
- 7.7 (end of test)
- Dissolved oxygen:
- 4.8 (end of test)
- Nominal and measured concentrations:
- 1000 ppm
- Details on test conditions:
- TEST SYSTEM
- Test vessel: aquarium made of glass.
- Size: 4 litres.
- No. of organisms per vessel: 10
TEST MEDIUM
- Source of dilution water: water aerated enough was used as dilution water. - Duration:
- 48 h
- Dose descriptor:
- other: TLm
- Effect conc.:
- > 1 000 other: ppm
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The sample resulted to be water soluble.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- TLm (48 h) > 1000 ppm
- Executive summary:
- The short-term toxic potential of the test
substance to orange-red killifish was investigated according to a specific
national testing guideline: JIS - 0102 - 1974. 10 fish were exposed to a
test concentration of 1000 ppm at a test temperature of 25 ± 1 °C. The
duration of the test was 48 h. The fish which passed mercuric chloride
inspection were used. Well-water aerated enough was used as the dilution
water. Survival rates in percentage were determined at 2 h, 24 h and 48 h.
The Median Tolerance Limit (48 h) resulted to be greater than 1000 ppm, therefore, the test substance can be considered as non-toxic to fish.
Conclusion
TLm (48 h) > 1000 ppm
Reference
Description of key information
Not harmful/toxic for fish after short-term exposures.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
The short-term toxic potential of the test substance to orange-red killifish was investigated according to a specific testing method: JIS - 0102 - 1974. 10 fish (which passed mercuric chloride inspection) were exposed to a test concentration of 1000 ppm over a period of 48 hours. Survival rates in percentage were determined at 2 h, 24 h and 48 h. The Median Tolerance Limit (48 h) resulted to be greater than 1000 ppm, therefore, the test substance has been judged as non-toxic to fish.
The study outcomes are confirmed by further information available on Direct Red 253 (on substance as itself and on the substance salificated by both sodium and triethanolammonium salts (50:50)). Unfortunately, only a short sheet of ecotoxicological data is currently available, thus reliability cannot be assigned; many details are missing on test procedures and on the study results. In any case, the LC50 values agree with that recorded in the abovementioned experiment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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