Registration Dossier
Registration Dossier
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EC number: 203-862-8 | CAS number: 111-36-4
Endpoint summary
Administrative data
Description of key information
Additional information
For fish (Lepomis macrochirus) the acute toxicity (LC50, 96 h) of n-butylamine, the hydrolysis product of n-butylisocyanate, was 32 mg/L.
The acute toxicity of n-butylamine, the hydrolysis product of n-butylisocyanate, to Daphnia magna is EC50 > 100 mg/L at 48 h.
In 72 h the effective concentration of n-Butylamine, the hydrolysis product of n-butyl isocyanate, which reduces the growth rate of aquatic algae by 50 %, is 51.1 mg/l .
The 16 h-EC0 of n-butyl isocyanate to P. putida is > 1000 mg/L. The 12 h-EC50 of n-butyl isocyanate to T. pyriformis is 10.96 mg/L.
Butyl isocyanate was shown to completely hydrolyze during the solution step, which took 6 minutes yielding n-butyl amine and 1,3-dibutyl urea as transformation products. Compared to the applied concentration of butyl isocyanate, 92 % n-butyl amine and only 8 % of 1,3-dibutyl urea were formed. Thus, n-butyl amine represents the main transformation product. Since the duration of the bio assay is quite greater than the dissipation time of butyl isocyanate, results obtained through the testing of n-butyl amine can be used as well to assess the risk of butyl isocyanate towards aquatic organisms. Effects of 1,3-dibutyl urea can be neglected due to the low concentration formed.
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