Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-074-5 | CAS number: 431-47-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Annex VIII of the REACH regulation mentions that the assessment of the toxicokinetic behaviour of the substance should be reported to the extent that can be derived from the relevant available information. From the search done for available data, it is reported that no known toxicity data is available for methyl trifluoroacetate.
The methanol hydrolytic half-life of methyl trifluoroacetate is less than 1 minute. Methanol and trifluoroacetic acid result from the reaction with water in the mucous membranes, upper respiratory tract, eyes and skin. Methanol is harmful and exposure to liquid or vapors may cause blindness or death. While the toxicity of trifluoroacetic acid is low, contact with the skin may cause burns. The acid diffuses into the affected tissue and destroys as it penetrates. Fumes may also be irritating. Wash any affected area for at least 15 minutes and treat as third degree burn even though appearance may not indicate severity of skin damage.
Thus, in the light of the above information, conducting a toxico-kinetic study for methyl trifluoroacetate seems scientifically unjustified.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Annex VIII of the REACH regulation mentions that the assessment of the toxicokinetic behaviour of the substance should be reported to the extent that can be derived from the relevant available information. From the search done for available data, it is reported thatno known toxicity data is available for methyl trifluoroacetate.
The methanol hydrolytic half-life of methyl trifluoroacetate is less than 1 minute. Methanol and trifluoroacetic acid result from the reaction with water in the mucous membranes, upper respiratory tract, eyes and skin. Methanol is harmful and exposure to liquid or vapors may cause blindness or death. While the toxicity oftrifluoroacetic acid is low, contact with the skin may cause burns. The acid diffuses into the affected tissue and destroys as it penetrates. Fumes may also be irritating. Wash any affected area for at least 15 minutes and treat as third degree burn even though appearance may not indicate severity of skin damage.
Thus, in the light of the above information, conducting a toxico-kinetic study for methyl trifluoroacetate seems scientifically unjustified. In addition, there is very low possibility of the chemical being ingested within the living system, except accidentally. If this occurs, there shall be no bioaccumulation due to injury to the internal organs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.