Registration Dossier
Registration Dossier
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EC number: 234-439-6 | CAS number: 12003-78-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information is given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Aluminium, compound with nickel (1:1)
- EC Number:
- 234-439-6
- EC Name:
- Aluminium, compound with nickel (1:1)
- Cas Number:
- 12003-78-0
- Molecular formula:
- Al.Ni
- IUPAC Name:
- aluminum - nickel (1:1)
- Test material form:
- aerosol dispenser: not specified
- Remarks:
- migrated information: aerosol
- Details on test material:
- Aerosols were generated from the powder mechanically through vibrating and compressed air.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 10 animals
provided with Purina cubed diet and tap water ad libitum
acclimation: 7 days
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- dust-laden air was piped to a 56 liters all glass exposure chamber with the test animal.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 1 h
- Concentrations:
- Nominal chamber concentration was 25 mg/L
Measured concentration was 2.2 mg/L - No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 2 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- All animals were considered normal through out the 14d oberservation period.
- Clinical signs:
- other: No signs of toxicity were obeserved under the test conditions.
- Body weight:
- No abnormal body weight gains were observed.
- Gross pathology:
- Observed at necropsy at 14d post-exposure: Increased incidence of pulmonary abnormalities such as areas of hemorrhage and atelectasis. Was considered to be moderate.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- No signs of toxicity were observed under test conditions.
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