Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 943-242-0 | CAS number: -
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (56 d) ≥ 1000 mg/kg dw (OECD 222, read-across)
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers to soil macroorganisms are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance neopentyl glycol dioleate (CAS 42222-50-4) was conducted. The source substance is representative to evaluate the toxicity of Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers to terrestrial organisms. Both substances are structurally very similar. The target substance is characterized as a diester of neopentylglycol esterified with mainly C18 unsaturated fatty acids. The main constituent of the source substance is the neopentyl glycol dioleate containing additional constituents of higher molecular weight. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13.
The study performed with the source substance 2,2-dimethyl-1,3-propanediyl dioleate (CAS 42222-50-4) to soil macroorganisms was performed according to OECD 222 (GLP; Amsel, 2013). The test organism Eisenia fetida was exposed to the nominal test concentrations of 62.5, 125, 250, 500 and 1000 mg/kg soil dw for 56 days. No significant effects on reproduction were observed during the study, and the NOEC was reported to be ≥ 1000 mg/kg dw.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers will not result in effects on soil macroorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
