Registration Dossier
Registration Dossier
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EC number: 252-487-6 | CAS number: 35285-68-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48h) = 10 mg/L for Daphnia magna (ISO 634115, full test), read-across
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 10 mg/L
Additional information
No studies investigating the short-term toxicity of sodium ethylparaben (CAS No. 35285 -68 -8) to aquatic invertebrates are available. Therefore, toxicity data of the corresponding acid ethylparaben (CAS No. 120 -47 -8) are used as read across.
This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as is explained within the analogue justification in section 13. Except for different cations (hydrogen vs. sodium) the anions of both the source and target substance have identical chemical structures. Since dissociation of the sodium salt under environmental conditions (pH 4 - 9) yields the same ionic species as the acidic form of the substance, this read across can be considered as justified.
For the toxicity of the analogue read across substance ethylparaben the following data are available:
Data on the short-term toxicity of ethylparaben to aquatic invertebrates are presented in the dossier “Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products” by the Danish Ministry of Environment and Energy (Madsen et al., 2001). Herein, results from a study according to ISO 634115 are cited. Daphnia magna were exposed to nominal concentrations of 1, 2, 5, 10, 20, 50 and 100 mg/L. The EC50 was determined to be > 10 mg/L to < 20 mg/L. The NOEC was determined to be 10 mg/L.
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