Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-551-9 | CAS number: 976-56-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Diethyl [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate
- EC Number:
- 213-551-9
- EC Name:
- Diethyl [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate
- Cas Number:
- 976-56-7
- Molecular formula:
- C19H33O4P
- IUPAC Name:
- diethyl (3,5-di-tert-butyl-4-hydroxybenzyl)phosphonate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult animals
- Weight at study initiation: about 3 kg
- Housing: single housing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 7 days
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: one test site on each animal shaved, the other test site shaved and abraded
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g
- Concentration: 0.5 g test substance moistened with 0.5 mL of water
VEHICLE
- Amount applied: 0.5 mL water - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 4 (2 males and 2 females)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm * 2.5 cm each of the two application sites
- Type of wrap if used: Gauze patches containing test material were secured by thin strips of adhesive tape, the entire trunk was wrapped with impervious plastic sheeting securely taped in place.
SCORING SYSTEM: according to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h / 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h / 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No dermal reactions at any timepoint.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
