Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-313-9 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List IV
- Author:
- Smyth Jr. HF, Carpenter CP, Weil CS
- Year:
- 1 951
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med. 4, 119-122.
- Reference Type:
- secondary source
- Title:
- 1,4-Dichlorobut-2-ene- CAS No: 764-41-0
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for 22th SIAM, UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dermal LD50 has been determined with rabbits, after 24-hour dermal exposure under occlusive conditions. Method described in: Smyth et al., J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-dichlorobut-2-ene
- EC Number:
- 212-121-8
- EC Name:
- 1,4-dichlorobut-2-ene
- Cas Number:
- 764-41-0
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,4-dichlorobut-2-ene
- Details on test material:
- - Name of test material (as cited in study report): 1,4-dichlorobut-2-ene.
- Analytical purity: no data.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- no data
- No. of animals per sex per dose:
- 6 per dose group (sex of the animals not reported)
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Statistics:
- Standard deviations calculated by the method of Thompson (1947)
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 735 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 557 - 960
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
