Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 943-007-2 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of the target substance Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) to aquatic invertebrates is not available. The assessment was therefore based on a study conducted with the structurally similar substances Isopropyl myristate (CAS 110-27-0) and Isopropyl palmitate (CAS 142-91-6) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The toxicity of the source substance Isopropyl myristate (CAS
110-27-0) was tested according to EU Method C.2 under GLP conditions
(Küch, 1995). The testing comprised three different methods. Method 1:
limit test 100 mg/L test substance and 5 min ultrasonic treatment;
Method 2: limit test 100 mg/L, 24 h stirring and removal of undissolved
test substance via filtration through glass fibre filter; Method 3: 3-5
times saturation, 24 h stirring. In all tests animals were swimming at
the water surface. Furthermore, using method 1, an oily film was
present. Method 1 (limit test without substance separation) resulted in
an EC50 < 100 mg/L (nominal), whereas in method 2 and 3 (both tests with
substance separation) the EC50 was established as greater than the water
solubility. In conclusion, the results indicate that physical effects
may occur in the prescence of undissolved test material.
In a second study the acute toxicity of the source substance Isopropyl
palmitate to Daphnia magna was tested under static conditions according
to EU Method C.2 and to GLP (Kirch, 1998), using a solution of test
material after removal of undissolved test material of 1000 and 3000
mg/L (nominal). No immobilized Daphnids were found, however animals were
swimming at the surface in both substance concentrations. Since the
analytical recovery rates were below 0.1%, the resulting EL50 (48 h) was
related to the nominal concentration (>3000 mg/L).
Based on the results of the read across substance toxic effects of Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) to aquatic invertebrates are not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
