Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline-Studie, ausführlich dokumentiert

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Reference substance name:
Penicillamin-Bleisalz
IUPAC Name:
Penicillamin-Bleisalz
Constituent 2
Reference substance name:
Bleisalz der 2-Amino-3-mercapto-3-methylbuttersäure
IUPAC Name:
Bleisalz der 2-Amino-3-mercapto-3-methylbuttersäure
Test material form:
other: solid
Details on test material:
- Analytical purity: >99.0%
- Lot/batch No.: 120595
- Expiration date of the lot/batch: mind. bis 05/2000

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
0.4
Remarks on result:
other: keine Temperaturangabe

Applicant's summary and conclusion

Conclusions:
Der Octanol-Wasser-Verteilungskoeffizient (logPow) von Penicillamin-Bleisalz wurde mittels HPLC-methode zu 0,4 bestimmt.