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EC number: 690-796-1 | CAS number: 420-16-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No study data is available for the test substance. Similar to all coordination complexes of boron trifluoride with organic and inorganic species (like alcohols, ethers, amines, sulfuric acid, sulfuric dioxide, etc) the complex of boron trifluoride and acetonitrile is extremely water sensitive and reacts even with moist air. In the instantaneous reaction with water as a first step acetonitrile and boron trifluoride dihydrates are formed. The latter undergoes further rapid hydrolysis to boric acid, fluoboric acid and tetrafluoroborate. Acute effects on daphnids were studied using the read across substances boric acid (CAS No 10043-35-3) sodium tetrafluoroborate (CAS No 13755-29-8) and acetonitrile (CAS No 75-05-8).
key (boric acid)
The 48-h acute toxicity of the read across substance boric acid (CAS No 10043-35-3) to Daphnia magna was studied under static conditions. Daphnids were exposed to solvent control and nominal concentrations of 54, 91, 151, 252, 420 and 700 mg B/L.
Mortality/immobilisation was observed daily. Animals were not fed during the study.
No mortality was observed up to 54 mg B/L. All animals were found dead in the two highest concentration groups. The 48-hour LC50 was determined to 133 mg B/L (Gersich, F.M., 1984).
supporting (tetrafluoroborate)
In the present publication (Bernot et al., 2005), the acute toxicities of imidazolium-based Ionic Liquids (ILs) to the water flea Daphnia magna was investigated. Acute toxicity of ILs (48-h median lethal concentration [LC50] value) was determined using standard U.S. Environmental Protection Agency (U.S. EPA) protocols. The acute effects of imidazolium-based ILs on survival of the crustacean Daphnia magna and their chronic effects on number of first-brood neonates, total number of neonates, and average brood size were studied. The toxicity of salts with Na+ as the cation and PF6-, BF4- as anions was also tested in order to determine if the imidazolium cation or the various anions influenced toxicity. Lethal concentrations of imidazolium ILs with various anions (X) ranged from a median lethal concentration (LC50) of 8.03 to 19.91 mg/L, whereas salts with a sodium cation (Na +X) were more than an order of magnitude higher (NaPF6 LC50, 9344.81 mg/L; NaBF4 LC50, 4765.75 mg/L). Thus, toxicity appeared to be related to the imidazolium cation and not to the various anions (e.g., Cl, Br, PF6, and BF4). Finally, the LC50 of sodium tetrafluoroborate being 4765.75 mg/L is the relevant read across information.
supporting (public references from 1977 -1991, focus on boron)
Several daphnia values are reported, including several studies of high quality. Acute values (24-48 hour EC50) range from 73 to 226 mg B/L for Daphnia magna. Data for other daphnids are reported but are of low reliability, also reported acute values in the 100-180 mg B/L range for Ceriodaphnia dubia and Simocephalus vetulus. Maier and Knight (1981) reported that water hardness had no effect on the acute toxicity to the midge Chironomus decorus, with a 48-hour EC50 of 1376 mg B/L.
Based on the results of the acute ecotoxicity tests using daphnids, LC50/EC50 was above 100 mg/L, indicating no toxicity triggering classification and labelling.
supporting (acetonitrile):
Two studies were performed with acetonitrile.
In the first study (Tong, Z., 1996), the test item was tested with daphnia magna. The LD50 (48 h) was 3600 mg/L.
In the acute toxicity study (Barahona-Gomariz, 1994), the LD50 (24 h) was 399.65 - 640.95 mg/L (depending on age).
Based on the results of the acute ecotoxicity tests using daphnids, LC50/EC50 was above 100 mg/L, indicating no toxicity triggering classification and labelling.
Conclusion:
Considering all cited and relevant LC50 values as a worst case
result the acute toxicity value for boron for daphnids at 133 mg B/L
can be applied to the reference substance boron trifluoride acetonitrile.
All cited and relevant LC50 values (for boron, ammonium
tetrafluoroborate, and acetonitrile) are above 100 mg/L.
Thus, based on the results of the acute ecotoxicity tests in daphnia no
classification and labelling is triggered.
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