Registration Dossier
Registration Dossier
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EC number: 212-344-0 | CAS number: 793-24-8
Endpoint summary
Administrative data
Description of key information
Additional information
Since 6PPD hydrolyses rapidly within a half- life of about 8 hours, experimental data for the hydrolysis products 4 -hydroxydiphenylamine, N-phenyl-p-benzoquinone monoimine and 1,3 -dimethylbutylamine was taken into account. A QSAR for 6PPD yielded a BCF of 569. Even considering uncertainties using a QSAR, this value indicates that the original substance does not meet the B-criterion of 2000. The QSAR for 6PPD was validated using experimental data and a QSAR for a higher homologue of the paraphenylenediamines ("8PPD"). The BCF of 8PPD was up to 1700.
The bioconcentration factor of the two main hydrolysis products of 6PPD, 4-anilinophenol (4-hydroxydiphenylamine) and its oxidised form N-Phenylphenyl-p-benzoquinone monoimine, ranges from 3.3 - 49 and < 1.2 - 23, respectively. The BCF values for 1,3-dimethylbutylamine range from 1.7 - 17. All three substances were investigated by the Chemicals Inspection & Testing Institute of Japan (CERI, 1995, National Institute of Technology and Evaluation 2002) according to OECD Guideline 305 C, using Cyprinus carpio as test organism.
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