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Diss Factsheets
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EC number: 203-564-8 | CAS number: 108-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline animal experimental study, published in peer reviewed literature, minor restrictions in reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- On the pharmacokinetics of the ethanol metabolite acetate: Elimination from the blood and cerebrospinal fluid
- Author:
- Freundt KJ
- Year:
- 1 973
- Bibliographic source:
- Drug Res. 23: 949-951
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- The distribution and elimination kinetics of acetate were determined from concentrations in plasma and cerebral spinal fluid following single intravenous doses of sodium acetate.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium acetate
- EC Number:
- 204-823-8
- EC Name:
- Sodium acetate
- Cas Number:
- 127-09-3
- Molecular formula:
- C2H4O2.Na
- IUPAC Name:
- sodium acetate
- Details on test material:
- - Name of test material (as cited in study report): Sodium acetate, analytical grade (Merck, Darmstadt)
- No further details
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- dog
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight: 15-25 kg
- Diet: Altromin dry pellets ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- maintained under constant conditions
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: Ringer solution
- Duration and frequency of treatment / exposure:
- Single dose
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3-6mmol/kg
- No. of animals per sex per dose / concentration:
- Total of 5 (sex not reported)
- Control animals:
- no
- Details on dosing and sampling:
- The dose was injected into the left femoral vein at a rate of 48 mmol/min. Blood samples for the determination of acetate using an enzymic method were withdrawn from the right femoral vein.
Results and discussion
- Preliminary studies:
- Background concentrations of acetate in plasma and cerebral spinal fluid were determined in man, dog and rabbit. Concentrations (mean±SD) in plasma were 0.065±0.007 (n=9), 0.090±0.012 (n=15) and 0.088±0.022umol/mL (n=5) for man, dog and rabbit respectively; concentrations in cerebral spinal fluid were 0.091±0.007 and 0.089±0.013 in man and dog respectively.
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- At plasma pH (7.4) only about 0.23% of the acetate was unionised and able to permeate across a lipid barrier. Over a 60 min period during which plasma concentrations of acetate were maintained at 22 umol/mL, the maximum concentration in cerebral spinal fluid (CSF) was approximately 20x lower than in plasma; the permeability (min-1) for distribution from plasma into CSF was 0.002±0.0009. The elimination half life from CSF was 14.6± 5.9 min.
- Details on excretion:
- Elimination half lives were 3.0±0.5, 4.0±0.3, 4.1±0.4 and 5.0±0.5 minutes at doses of 3, 4, 5 and 6 mM/kg, respectively.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Acetate distributed from plasma into cerebral spinal fluid and was rapidly eliminated. Elimination half lives were 3.0±0.5, 4.0±0.3, 4.1±0.4 and 5.0±0.5 minutes at doses of 3, 4, 5 and 6 mmol/kg, respectively
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