Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-569-3 | CAS number: 26266-58-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 982
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
Materials and methods
- Objective of study:
- distribution
- excretion
- Principles of method if other than guideline:
- The radiolabelled test substance was orally administered to rats and the excretion pathways were investigated.
- GLP compliance:
- no
Test material
- Reference substance name:
- Anhydro-D-glucitol trioleate
- EC Number:
- 247-569-3
- EC Name:
- Anhydro-D-glucitol trioleate
- Cas Number:
- 26266-58-0
- Molecular formula:
- C60H108O8
- IUPAC Name:
- 1,4-anhydro-2,3,6-tri-O-oleoyl-L-iditol
- Details on test material:
- - Name of test material (as cited in study report): Sorbitan trioleate
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: The test substance was prepared with a 14C-label in the sorbitol or the oleate moieties or 14C-sorbitan-labelled esters were prepared.
- Details on study design:
- After administration of sorbitan 14C-trioleate, the appearance of 14C-CO2 in the expired air, 14C-label in the faeces and gastrointestinal tract, liver, carcass was determined.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- After administration of sorbitan 14C-trioleate, the appearance of 14C-CO2 reached a peak at about 6 hours in the expired air and amounted to 30-35% of administered label. The faeces and gastrointestinal tract contained about 42% of the 14C-label, indicating that it was incompletely absorbed, and 3% appeared in the urine; the liver contained about 3% and the carcass about 22%. After administration of the 14C-sorbitan-labelled-ester, less than 2% of the label was recovered as 14C-CO2; the proportions not absorbed were 24% from a water emulsion and 37% from a solution in oil; the proportions recovered of that absorbed were as follows: urine 88%, expired air 5%, liver 1%, carcass 6%.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
