Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-861-6 | CAS number: 4098-71-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: While the study documentation may be regarded as sufficient (short report) the statistical evaluation is less reliable due to low number of animals.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1967
Materials and methods
- Principles of method if other than guideline:
- other: "standard"
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS: Isophorone diisocyanate submitted by P.G. Naylor, Division Chemicals and Plastics Research and Development, South Charleston, W.Va. (USA); sponsor's ID 38-MPW-105 / 29-DS-10-5; internal ID 30-182
Constituent 1
Test animals
- Species:
- rat
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: no vehicle
- Doses:
- 106; 212; 423; 846 mg/kg bw
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 222 mg/kg bw
Any other information on results incl. tables
RS-Freetext:
MORTALITY:
- Number of deaths at each dose:
0.8 ml/kg: 5/5 within less than 1 day
0.4 ml/kg: 3/5 within 1 day
0.2 ml/kg: 4/5 within 1 day
0.1 ml/kg: 0/5
CLINICAL SIGNS: slight tremors, heavy breathing
NECROPSY FINDINGS: congestion throughout the lungs and the abdominal viscera
LD50 = 0.21 (0.13-0.35) ml/kg = 222 (138-370) mg/kg
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
