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Diss Factsheets
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EC number: 604-112-6 | CAS number: 139147-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000-02-15 until 2000-05-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Silane CP 2
- Physical state: liquid
- Analytical purity: 96.3% (GC)
- Impurities (identity and concentrations): as stated in substance data
- Composition of test material, percentage of components: as stated in substance data
- Purity test date: 1999-10-29
- Lot/batch No.: 10466 QB
- Expiration date of the lot/batch: 2002-10-29
- Stability under test conditions: reaction to hydrolysis product
- Storage condition of test material: in original container, at room temperature, in the dark
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Duplicate samples from the freshly prepared test media of all test concentrations and the control were taken at the start of the test (6.5 hours after test media preparation). For the determination of the stability of the test item under the test conditions, respectively the maintenance of the test item concentrations during the test period, samples were taken in duplicate out of all test media and the control on day 2 and day 4 of exposure. From the test item concentration of nominal 100 mg/L only stability samples were taken in duplicate after 24 hours test duration, since all fish were already dead after 24 hours.
The samples were stored in the refrigerator and protected from light until analysis were performed.
In parallel to the test start stability samples were prepared. A stock solution of the test item was prepared in acetone. This stock solution was used to fortify samples of the test water at the level of 5, 20 and 100 mg test item/L test water.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Adequate amounts of the test item were mixed into small amounts of test water by ultrasonic treatment for 2 x 15 minutes and intense stirring for approx. 15 minutes. Then, the suspensions were filled into aquaria and were filled up with test water to prepare the desired test concentrations. The main part of the test item react within 6 hours to the hydrolysis product dicyclopentylsilanediol. Therefore, the test media were prepared 6.5 hours before introduction of test fish (= start of the test).
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- The test fish were obtained from City Zoo, 64283 Darmstadt, Germany.
Male and female Zebra fish (Brachydanio rerio)
Age and size: juveniles; mean body length in the test was 3.06+/- 0.21 cm, the mean body wet weight was 0.28 +/- 0.05 g
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- not applicable
Test conditions
- Hardness:
- 2.5 mmol/L (= 250.0 mg/L) as CaCO3
- Test temperature:
- 21 °C
- pH:
- 7.1 to 8.1
- Dissolved oxygen:
- at least 7.8 mg/L or higher
- Nominal and measured concentrations:
- Nominal: 4.6, 10, 21, 46, 100 mg/L
Measured: -, -, 19.5, 41.2; 77.8 (part of the test item lying on the bottom) mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 25 litre glass aquaria with 10 litre test medium
- Aeration: slightly during test
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water in accordance with Guidelines
- Ca/mg ratio: 4:1
- Alkalinity: 0.8 mmol/L
OTHER TEST CONDITIONS
- Photoperiod: 16 h light : 8 h dark
- Light intensity: 670 - 920 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Observation approx. 2, 24, 48, 72 and 96 hours test duration
- Reference substance (positive control):
- not required
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 49.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Remarks:
- hydrolysis product
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CI: 32.0 mg/L to 75.9 mg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 21 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Remarks:
- hydrolysis product
- Basis for effect:
- mortality (fish)
- Remarks:
- ; symptoms of intoxication
- Reported statistics and error estimates:
- The LC 50 and the 95 % confidence limits were calculated by Moving average interpolation.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Substance is harmful to fish.
- Executive summary:
The objective of this 96-hour study was to evaluate the acute toxicity of the test item to fish. The test has been performed in accordance with EEC-/OECD Guideline under GLP. Due to hydrolytical reaction of the test item in water the hydrolysis product dicyclopentylsilanediol was tested. An LC50 (96 h) of 49.3 mg/L has been determined. The NOEC in this test was 21 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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