Registration Dossier
Registration Dossier
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EC number: 221-921-6 | CAS number: 3282-30-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound pivaloyl chloride (CAS 3282-30-2): No data available.
Hydrolysis product pivalic acid (CAS 75-98-9): with high probability acutely not harmful to algae.
Hydrolysis product HCl (CAS 7647-01-0): Acutely very toxic for aquatic algae (pH dependent).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 979 mg/L
- EC10 or NOEC for freshwater algae:
- 246 mg/L
Additional information
No data are available for the parent compound pivaloyl chloride (CAS 3282-30-2). However, the parent compound rapidly hydrolyses in contact with water and forms pivalic acid (CAS 75-98-9) and HCl (CAS 7647-01-0). Therefore, the toxicity to aquatic green algae and cyanobacteria will be assessed based on the information available for the hydrolysis products pivalic acid and HCl.
Parent compound pivaloyl chloride:
No data available.
Hydrolysis product pivalic acid:
The toxicity of the hydrolysis product pivalic acid was tested in a GLP
compliant study performed according to OECD 201 with Raphidocelis
subcapitata (previous name Pseudokirchneriella subcapitata
as test organism (Exxon, 2003). The 72-h ErC50 was found to be 979 mg/L.
The NOEC is reported to be 246 mg/L. The test item concentration was
analytically verified and effect values are therefore based on nominal
test concentrations.
Hydrolysis product HCL:
The toxicity of the hydrolysis product HCl was tested in a GLP study according to OECD 201 with R. subcapitata (previous name P. subcapitata (MITI, 1999; peer reviewed data: OECD SIDS, 2002). The 72-h ErC50 was 0.492 mg/L (acid equivalent to pH 5.3). The NOEC was 0.097 mg/L (acid equivalent to pH 6).
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