Registration Dossier
Registration Dossier
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EC number: 701-392-2 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A key study to assess the acute toxicity of the test item to Daphnia
magna was performed in accordance with OECD Guideline No 202.
Following a preliminary range-finding test, twenty daphnids (4
replicates of 5 animals) were exposed to a Water Accommodated Fraction
(WAF) of the test item at single nominal loading rate of 100 mg/L for 48
hours at a temperature of 21-22 °C under static test conditions. The
number of immobilized Daphnia and any adverse reactions to exposure were
recorded after 24 and 48 hours.
It was considered unnecessary and unrealistic to test at loading rates
in excess of 100 mg/L loading rate WAF.
The 48-hour EL50 (Median Effective Loading Rate) for the test item to
Daphnia magna based on nominal loading rates was greater than 100 mg/L
loading rate WAF. The No Observed Effect Loading rate was 100 mg/L
loading rate WAF.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Marine water invertebrates
Marine water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 6.8 mg/L
Additional information
A key study to assess the acute toxicity of the test item to Daphnia magna was performed in accordance with OECD Guideline No 202.
Following a preliminary range-finding test, twenty daphnids (4 replicates of 5 animals) were exposed to a Water Accommodated Fraction (WAF) of the test item at single nominal loading rate of 100 mg/L for 48 hours at a temperature of 21-22 °C under static test conditions. The number of immobilized Daphnia and any adverse reactions to exposure were recorded after 24 and 48 hours.
It was considered unnecessary and unrealistic to test at loading rates in excess of 100 mg/L loading rate WAF.
The 48-hour EL50 (Median Effective Loading Rate) for the test item toDaphnia magnabased on nominal loading rates was greater than 100 mg/L loading rate WAF. The No Observed Effect Loading rate was 100 mg/L loading rate WAF.
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