Registration Dossier
Registration Dossier
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EC number: 500-085-9 | CAS number: 35176-06-8 1 - 6.5 moles propoxylated
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Diethanolamine, propoxylated was tested in the modified Local Lymph Node Assay (IMDS) in female NMRI mice using dermal application of up to and including a 50% concentration. The "positive level" of ear swelling which is 2 x 10-2 mm increase, i.e. about 10% of the control values, has not been reached or exceeded in any dose group. Nevertheless a statistically significant increase has been detected after administration of the high concentration of the test item in ear weights. Although this effect is not corroborated by increase in ear swelling an irritant potential can not be excluded.
It has to be clarified that the "positive levels" mentioned above are exclusively defined for the NMRI outbred mice used for this study. Such positive limits have to be calculated for each strain of mice individually.
The body weights of the animals were not affected by any treatment. Based on these results, classification of Diethanolamine, propoxylated as skin sensitiser is not warranted.
Migrated from Short description of key information:
Not a sensitiser in a modified Local Lymph Node Assay.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
The LLNA result indicates that the substance does not meet the criterion for classification as a skin sensitiser.
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