Methyl vinyl ether

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions (report not available for submitter, no further details available)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

no

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Methyl vinyl ether

EC Number:

203-475-4

EC Name:

Methyl vinyl ether

Cas Number:

107-25-5

Molecular formula:

C3H6O

IUPAC Name:

methoxyethene

Details on test material:

methyl vinyl ether (MVE)
no further data

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Animals were 52 days old at the time of exposure. Rats were identified by toe clipping, and were housed 5 per cage. Animals were kept in rooms designed to maintain adequate environmental conditions, and were given a commercial diet and municipal water ad libitum.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

other: presumably whole body

Vehicle:

other: air

Details on inhalation exposure:

The target chamber concentration was 19,500 ppm (47 mg/L), 75% of the lower explosive limit for MVE. Chamber concentration was analyzed by gas chromatography 27 times during the 4-hour exposure. Nominal concentration was also calculated based on test material used and chamber airflow. Relative humidity and temperature of the chamber were recorded during the exposure.

Analytical verification of test atmosphere concentrations:

yes

Remarks:

(analyzed by gas chromatography)

Duration of exposure:

4 h

Concentrations:

20165 ppm (analytical) or 48 mg/L

No. of animals per sex per dose:

5

Details on study design:

Animals were observed for 14 days following the vapor exposure. Body weights were taken pre-exposure, and on days 7 and 14. Gross pathology was performed on all animals. Five male and five female Sprague-Dawley rats were used for the study.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

48 mg/L air (analytical)

Exp. duration:

4 h

Remarks on result:

other: original value: 20165 ppm

Mortality:

no

Clinical signs:

other: no

Body weight:

no data on results

Gross pathology:

no effects

Any other information on results incl. tables

The analytical concentration of MVE in the chamber was 20,
165 ppm. Temperature and relative humidity of the chamber
was maintained adequately for the species. 

There were no clinical signs of toxicity noted on the day of
exposure or during the 14 day post-exposure period. There
was likewise no treatment-related mortality during the 14
day period, and no macroscopic findings noted at necropsy.
The LC50 was > 20,165 ppm.

Applicant's summary and conclusion

Conclusions:

No mortality and no clinical signs in rats exposed for 4 h to 20165 ppm (48 mg/L) in a acute inhalation toxicity study; LC50>48 mg/L.