Registration Dossier
Registration Dossier
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EC number: 219-006-1 | CAS number: 2312-35-8
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 105
- Deviations:
- not specified
- GLP compliance:
- not specified
- Key result
- Medium:
- acetone
- Solubility:
- > 200 g/L
- Key result
- Medium:
- methanol
- Solubility:
- > 200 g/L
- Key result
- Medium:
- toluene
- Solubility:
- > 200 g/L
- Key result
- Medium:
- other: dichloromethane
- Solubility:
- > 200 g/L
- Key result
- Medium:
- other: hexane
- Solubility:
- > 200 g/L
- Test substance stable:
- not determined
- Conclusions:
- Under the conditions of the test, the solubility of the test material in hexane, toluene, dichloromethane, methanol and acetone was >200 g/L.
- Executive summary:
In a solvent solubility study conducted in accordance with standardised guideline OECD 105, the solubility of the test material in a number of solvents was determined. Under the conditions of the test, the substance was determined to be soluble in all the solvents tested.
Reference
The test material dissolved in all of the solvents.
Description of key information
Solubility in organic solvents >200 g/L; study conducted in accordance with OECD Guideline 105; Akhtar, 1988
Key value for chemical safety assessment
Additional information
The solubility of the test material in five organic solvents (hexane, toluene, dichloromethane, methanol and acetone) at 20 ºC was determined to be >200 g/L. In a separate study, the test material was found to be completely miscible in ethyl acetate.
The study performed on the five organic solvents was selected as the key study in the basis that it covers more substances and provided a quantified figure of the solubility of the test material. The study was conducted to a standardised guideline and was assigned a reliability score of 2. The supporting study was performed in line with GLP, and to a standardised guideline, and was assigned a reliability score of 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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