Registration Dossier
Registration Dossier
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EC number: 235-627-0 | CAS number: 12389-75-2
Endpoint summary
Administrative data
Description of key information
Additional information
Three acute freshwater fish studies were assessed for this endpoint. Two limit tests and one actual determined LC50 value are available. The actual determined concrete LC50 value is used as key value and expressed as DTPA-FeNaH amounts to 1036 mg/L.
One valid chronic study with the crimson-spotted rainbowfish was available for assessment. Based on a 28 -day exposure with the crimson spotted rainbowfish, the NOEC for DTPA-FeHNa was 119 mg/Lbased on a lack of effects on reproduction.
Five acute toxicity tests with aquatic invertebrates were assessed for this endpoint, and all studies were found to be of good quality and reliable for use in the risk assessment process. The 48-hour LC50 for Daphnia carinata, a freshwater species, was 245 mg/L DTPA acid, which is equivalent to 291 mg/L DTPA-FeNaH. The 96-hour LC50 for Crangon crangon, a saltwater species, was 6020 mg/L pentasodium DTPA, which is equivalent to 5598 mg/L DTPA-FeNaH.
Two chronic freshwater studies with DTPA (free acid) were conducted with Daphnia carinata. The 18-day NOEC for reproduction in Daphnia carinata was equivalent to 59 mg/L DTPA-FeHNa.
A well performed study with DTPA-FeHNa is available for algae. However, due to the photo-instability of the compound and coloration of test solutions, actual measured concentrations showed some unexpected results, making it difficult to conclude based on these geometric mean measured values. Still, based on actual and nominal concentrations the chronic ErC10 value was confirmed > 1 mg/L, indicating low hazard to the environment.
Additional well performed studies with EDTA-FeNa, without the indicated issues above, confirm the low toxicity to algae of these iron chelates, when micronutrient scavenging is taken into account in the experimental set-up.
If not, these substances possess properties indicating a (acute) hazard to algae. However, the effect is associated with the chelation of essential nutrients and is not considered a relevant environmental hazard in view of the abundance of such nutrients in the aquatic environment.
Taken the most reliable data together, the lowest chronic aquatic toxicity value for DTPA-FeHNa is the 18 -day NOEC of 59 mg/L based on D. carinata reproduction. Daphnids are considered the most sensitive species and thus most relevant to consider for environmental risk assessment.
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