Registration Dossier
Registration Dossier
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EC number: 220-150-2 | CAS number: 2643-07-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro studies:
The test substance was tested for mutagenicity in a combined Ames test equivalent or similar to OECD TG 471 and E. coli bacterial reverse mutation assay equivalent and similar to OECD TG 472. The test substance was mutagenic with S. typhimurium strain TA 100, but not with the other test strains (S. typhimurium TA 1537 and TA 98; E.coli WP2 uvrA). In the presence of S-9 mix, the mutagenicity with S. typhimurium TA 100 was potentiated and the compound became also mutagenic with E. coli WP2 uvrA and slightly with S. typhimurium TA 98 (BASF AG, 1980).
The test substance was asessed for its potential to induce gene mutations at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus in Chinese hamster ovary (CHO) cells in vitro. This test was performed according to OECD TG 476 in compliance with GLP. Following the results of this study, the test substance is considered to induce forward mutations in the HPRT locus assay under in vitro conditions in CHO cells in the absence of metabolic activation (BASF SE, 2010).
In a GLP guideline study according to OECD TG 473 the test substance was considered to have a chromosome-damaging (clastogenic) effect under in vitro conditions in V79 cells in the presence of metabolic activation (BASF SE, 2009).
In vivo studies:
No studies are available for assessment.
Short description of key information:
Genetic toxicity in vitro:
- Ames test: positive
- HPRT test: positive
- Chromosomal aberration test: positive
Endpoint Conclusion:
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- Possible risk of irreversible effects, R68 (Muta. Cat. 3)
GHS classification according toAnnex I 1272/2008 CLP (EU GHS):
- Muta. Cat. 2
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