Registration Dossier
Registration Dossier
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EC number: 939-725-0 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referenced sources in an international report.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Dimethylformamide, SIDS Initial Assessment Report For SIAM 13
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP PUBLICATIONS
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N-dimethylformamide
- EC Number:
- 200-679-5
- EC Name:
- N,N-dimethylformamide
- Cas Number:
- 68-12-2
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N,N-dimethylformamide
- Test material form:
- not specified
- Details on test material:
- N,N-Dimethylformamide, purity 99%, about 1 % (weight) Methanol, traces of Monomethylformamide and Formamide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino rabbits
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: concentration: undiluted
- Controls:
- not specified
- Amount / concentration applied:
- Amount applied: about 0.5 ml.
- Duration of treatment / exposure:
- Duration of exposure: 20 hours
- Observation period:
- Observation continued until the findings disappeared.
- Number of animals:
- 4
- Details on study design:
- The neat test substance (about 0.5 ml) was administered for 20 hours on the shaved back of 4 albino rabbits. For this purpose a 2.5 cm x 2.5 cm big patch was soaked with the test substance and applied onto the skin and fixed with a bandage. After removal of the bandage the application site was examined and in case of findings, observation continued until the findings disappeared.
Results and discussion
Any other information on results incl. tables
Only one of the four animals showed faint redness on the first day after removal of the bandage. On the second day there were no more findings. The other three animals were without any findings.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- N,N-dimethylformamide was not found irritant to skin.
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