Registration Dossier
Registration Dossier
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EC number: 241-866-1 | CAS number: 17927-72-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 149087
- Year:
- 2 011
- Bibliographic source:
- ACToR(Aggregated Computational Toxicology Resource);
- Reference Type:
- publication
- Title:
- Genotoxic Potentiality & DNAbinding Propertie of Acetylacetone,Maltol &their Aluminum(Iii) & Chromium(Iii)Neutral Comlexes;
- Author:
- Gava,C,et.al.;
- Year:
- 1 989
- Bibliographic source:
- Toxicol..Environ. Chem; 22(1-4):149-57,
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- STANDARD PLATE METHOD.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Chromium(III) 4-oxopent-2-ene-2-olate
- EC Number:
- 244-526-0
- EC Name:
- Chromium(III) 4-oxopent-2-ene-2-olate
- Cas Number:
- 21679-31-2
- IUPAC Name:
- chromium(3+) tris(2,4-dioxopentan-1-olate)
- Test material form:
- not specified
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium, other: TA92
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 98
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 0.9-48 umol/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium, other: TA 92
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Genetic toxicity of Chromium (III) 4-oxopent-2-ene-2-olate to Salmonella typhimurium TA92, TA98 and TA100 is found to be negative without
metabolic activation at concentration of 0.9-48 umol/plate. - Executive summary:
Genetic toxicity of Chromium (III) 4-oxopent-2-ene-2-olate to Salmonella typhimurium TA92, TA98 and TA100 is found to be negative without metabolic activation at concentration of 0.9-48 umol/plate.
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