Registration Dossier
Registration Dossier
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EC number: 204-984-4 | CAS number: 130-26-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The minimal inhibitiory concentration (MIC) value of clioquinol in microorganism (Mycobacterium tuberculosis) in a 8 hr study on the basis of growth inhibition effect was estimated to be 6.25 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 25.215 mg/L
Additional information
Weight of evidence studies reviewed for toxicity to microorganisms from reliable sources having Klimish rating 2.
The summary of the results are presented below
Sr.no |
Endpoint |
Effect concentration |
Spicies |
Effect |
Source |
1 |
MIC |
6.25 mg/l |
Mycobacterium tuberculosis |
Growth inhibition |
Antimicrobial Agents and Chemotherapy |
2 |
IGC50 |
25.21514 mg/l |
Tetrahymena pyriformis |
Growth inhibition |
SSS QSAR |
3 |
IC50 |
589.2197 mg/l |
Tetrahymena pyriformis |
Growth inhibition |
SSS QSAR |
By applying weight of evidence approach to the target chemical clioquinol,toxicity to microorganism (Mycobacterium tuberculosis and tetrahymena pyriformis) in a 48 hrs to 8 days study on the basis of growth inhibition study was found to vary between MIC = 6.25 mg/l and IGC50 = 25.21514 mg/L to 589.21 mg/l .
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