Registration Dossier
Registration Dossier
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EC number: 201-911-8 | CAS number: 89-48-5
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: non-GLP and not OECD compliant study
Data source
Reference
- Reference Type:
- publication
- Title:
- Enhancement in skin permeation of 5-aminolevulinic acid using l-menthol and its derivatives
- Author:
- Tokuoka Y, Suzuki M, Ohsawa Y, Ochiai A, Ishizuka M, Kawashima N
- Year:
- 2 008
- Bibliographic source:
- PMID:18568909 Drug Dev Ind Pharm 34(6):595-601
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Enhancing effect of l-menthyl acetate on skin permeation of 5-aminolevulinic acid (ALA) through Yucatan micropig full-thickness skin using a Franz-type diffusion cell
- GLP compliance:
- no
Test material
- Reference substance name:
- Menthyl acetate
- EC Number:
- 201-911-8
- EC Name:
- Menthyl acetate
- Cas Number:
- 89-48-5
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 5-methyl-2-(propan-2-yl)cyclohexyl acetate
Constituent 1
- Radiolabelling:
- no
Results and discussion
Any other information on results incl. tables
Over 16 h the cumulative amount of 5-aminolevulinic acid (ALA) is obviously the largest in the case of l-methyl acetate.
This would be caused by the small difference in inorganic/organic value ratio (0.33), or hydrophobicity of terpene. Permeability coefficient increased with decreasing inorganic/organic value ratio, or with increasing hydrophobicity of l-menthol and his derivative, reaching the maximum in the system with l-menthyl acetate. This finding suggests that l-menthyl acetate has the optimal hydrophobicity of l-menthol derivative for enhancing ALA skin permeation.
Applicant's summary and conclusion
- Conclusions:
- l-menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.
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